This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
5-Azacytidine is a chemical analog of the nucleoside cytidine that incorporates into DNA and inhibits DNA methylation
At low doses, 5-azacytidine irreversibly binds the enzyme DNA methyltransferase (DNMT)
Applications
5-Azacytidine has been used for cardiomyocyte differentiation from mesenchymal stem cells
It has been used as a potent DNMT inhibitor in the study of tumor cell proliferation and induction of gene expression following demethylation
5-Azacytidine can globally change histone modification patterns