Bioactive Small Molecules

Thapsigargin is a naturally occurring sesquiterpene lactone isolated from the umbelliferous plant Thapsia garganica. This tumor promoter releases Ca2++ from intracellular stores by specifically inhibiting the endoplasmic reticulum Ca2++-ATPase. It does n

Typically used to equilibrate intracellular and extracellular Ca2+ concentrationsTo permit Mn2+ to enter cell to quench intracellular dye fluorescenceAlthough the intrinsic fluorescence of A-23197 is too high for use with UV-excitable calcium indicators

The unusually high Stokes shift of ANTS in water (>150nm) separates this from much of the autofluorescence of biological samplesANTS has also been employed as a neuronal tracer

Anilinonaphthalene sulfonates (ANS) are essentially nonfluorescent in water, only becoming appreciably fluorescent when bound to membranes. This property makes it a sensitive indicator of protein folding, conformational changes and other processes that m

Penicillin-binding proteins, present on the cytoplasmic membranes of eubacteria, can be detected with BOCILLIN FL penicillin and BOCILLIN 650/665 penicillin.Dissolve in high-quality anhydrous DMSO or water for a stock concentration of 1 to 10 mM.

With its nonpolar structure and long-wavelength absorption and fluorescence, BODIPY™ 493/503 can be used as a stain for neutral lipds and as a tracer for oil and other nonpolar lipids.We recommend dissolving in high-quality anhydrous DMSO to attain a sto

With its nonpolar structure and long-wavelength absorption and fluorescence, BODIPY™ 505/515 can be used as a stain for netural lipids and as a tracer for oil and other nonpolar lipids.To make a concentrated stock solution from 1–5 mM, dissolve in either

Prazosin is a high-affinity antagonist for the a1-adrenergic receptor. The green-fluorescent BODIPY FL prazosin derivative can be used to localize and detect the a1-adrenergic receptor.Cell Analysis, Cell Viability, Proliferation and Function, Cellular I

The fungal metabolite brefeldin A (BFA) has multiple targets in cells and has proven valuable for dissecting the cellular processes, including vesicle formation and kinesin distribution, involved in exporting newly synthesized proteins. We are pleased to

The synthetic steroid hormone dexamethasone binds to the glucocorticoid receptor, producing a steroid-receptor complex that then localizes in the nucleus and regulates gene transcription. The green fluorescent analog, fluorescein dexamethasone should be

DPX (p-xylene-bis-pyridinium bromide) can be used in membrane fusion or permeability assays with the polyanionic, polar tracer dye ANTS (A350).Cell Analysis, Cell Tracing & Tracking, Neuronal Tracing

The fluorescein-5-(and-6)-sulfonic acid can be used as a non-fixable polar tracer to investigate fusion, lysis and gap-junctional communication.Cell Analysis, Cell Tracing & Tracking, Cell Viability, Proliferation & Function, General Cell Tracing, Ionic

The phosphonate antibiotic FR-31564 (fosmidomycin) is an effective antimalarial agent that functions by blocking a mevalonate-independent pathway of isoprene synthesis. The antibiotic activity of FR-31564 is potentiated by glucose 1-phosphate. FR-31564 i

Ionomycin is an effective Ca2+ ionopohre that is commonly used to both modify intracellular Ca2+ concentrations and to calibrate fluorescent Ca2+ indicators when studying the regulatory properties of Ca2+ in cellular processes. Ionomycin also transports

Jasplakinolide is a potent inducer of actin polymerization in vitro by stimulating actin filament nucleation. Jasplakinolide competes with phalloidin for actin binding (Kd = 15nM).Cell Analysis, Cell Structure, Cytoskeleton