Citrate is an intermediate in the TCA cycle and fatty acid synthesis. It is an allosteric modulator of acetyl-CoA carboxylase, the enzyme that regulates the conversion of acetyl-CoA to malonyl-CoA. It has anticoagulant activity and is a calcium chelator. Its function is to break protein cross-links; thus, unmasking antigens and epitopes in formalin-fixed and paraffin embedded tissue sections, resulting in enhancing staining intensity of antibodies.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsCitrate is an intermediate in the TCA cycle and fatty acid synthesis. It is an allosteric modulator of acetyl-CoA carboxylase, the enzyme that regulates the conversion of acetyl-CoA to malonyl-CoA. It has anticoagulant activity and is a calcium chelator. Its function is to break protein cross-links; thus, unmasking antigens and epitopes in formalin-fixed and paraffin embedded tissue sections, resulting in enhancing staining intensity of antibodies.
SolubilityFully miscible in water. Insoluble in ethanol.
NotesStable under recommended storage conditions. Incompatible with oxidizing agents and heat.