This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Hydroxyurea is a member of the class of urea that shows antineoplastic, immunomodulatory, radical scavenger, and antimitotic activities.
• It has inhibitory activity against nucleic acid synthesis.
• It also inhibits ribonucleoside diphosphate reductase, an enzyme necessary to convert ribonucleoside diphosphate into deoxyribonucleoside diphosphate, preventing cells from leaving the G1/S phase of the cell cycle
Applications
• Hydroxyurea has an anti-retroviral activity, inhibiting human immunodeficiency virus type 1 (HIV-1) DNA synthesis in peripheral blood lymphocytes, decreasing the amount of intracellular deoxynucleotides
• This compound also has a radio sensitizing activity, maintaining cells in the radiation-sensitive G1 cell cycle phase and, consequently, interfering with DNA repair
• It has been used for cell cycle synchronization in human breast carcinoma cells
• This compound presents inhibitory activity in cell adhesion and motility assay in ccRCC Caki (HTB-47) and CD9 knockdown cells