Melatonin acts as a neurohormone that upregulates antioxidant enzymes and inhibits rat NOS1. It also acts as a particularly significant endogenous antioxidant. Melatonin is a rat NOS1 (nNOS) inhibitor. Melatonin is an activator of MEL-1A-R and MEL-1B-R.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Melatonine is a hormone produced by the pineal gland that shows several biological activities, including the somnolence, sleep-wake cycle, circadian rhythm, stress response, aging, and immunity activities
• It shows antioxidant, autocoid, paracoid, hormonal, anti- inflammatory and anti-apoptotic activities
Applications
• Melatonin shows neurohormonal activity and can upregulate antioxidant enzymes and inhibit rat NOS1
• Melatonin has been reported to be an activator of MEL-1A-R and MEL-1B-R
• The production and secretion of melatonine are dependent on beta-adrenergic receptor function
• During melatonine synthesis, the essential amino acid L-tryptophan is used as a precursor
• This compound inhibits apoptosis in immune cells and neurons, and enhances apoptotic cell death of cancer cells
• It can inhibit proliferation and metastasis of breast cancer cells by modulating Rho-associated kinase protein-1 expression