This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General description
• Mitomycin C is a water-soluble, blue-violet crystalline powder, unstable in light and acidic conditions, but maybe stably stored at 2-8°c
• Bio-reduced mitomycin C generates oxygen radicals, alkylates DNA, and produces inter-strand DNA cross-links, thereby inhibiting DNA synthesis
Applications
• Mitomycin C is preferentially toxic to hypoxic cells that are resistant to cancer therapy, and is therefore used to study its potential therapeutic effect on advanced stages of cancer
• At high concentrations, mitomycin C inhibits RNA and protein synthesis and demonstrates strong antibiotic properties towards both Gram-positive and Gram-negative bacteria