Pimaricin is an amphoteric antibiotic from Streptomyces chattanoogensis. It is used as an ergosterol and cholesterol binding agent to study lipid bilayer dynamics. It is used to study the pleitropic regulator AdpAch and the gamma-butyrolactone regulatory system of Streptomyces chattanoogensis.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Natamycin is a member of the macrolide antibiotic class, compounds originally derived from Saccharopolyspora erythraea, a type of soil bacteria
• Natamycin is an amphoteric compound with both acid and basic properties
• Natamycin exhibits antifungal activity • Natamycin exerts its effects by binding sterols within fungal cell walls and increasing membrane permeability, leading to a loss of homeostasis within the cell
Application
• Natamycin is suitable for use in the laboratory study of fungal keratitis and other infections of fungal origin
• Natamycin may also be used in laboratory research of cell physiology and mechanisms of antibiotic resistance