siRNA - Pages 2

The Silencer™ Human Apoptosis siRNA Library provides investigators with a focused siRNA screening platform targeting apoptosis genes and enabling a detailed analysis of the apoptotic signaling pathway. The Silencer Human Apoptosis siRNA Library includes

The Silencer™ Human Cancer Genome siRNA Library contains 1572 Ambion™ Silencer siRNAs targeting 524 gene targets that are commonly affected in cancers. The library was designed using the most up-to-date genome databases, including the NCBI RefSeq databas

Proteins that regulate cell division are crucial for controlling cell growth and are therefore potentially important drug targets. The Silencer™ Human Cell Cycle Regulation siRNA Library includes 4,398 Ambion™ Silencer siRNAs targeting 1,466 genes. These

Cell surface receptors are specialized integral membrane proteins that take part in communication between the cell and its surroundings. Extracellular signaling molecules, typically hormones, neurotransmitters, cytokines, growth factors and cell recognit

DNA surveillance proteins monitor DNA integrity, and they can activate cell cycle checkpoints and DNA repair pathways in response to DNA damage. This can prevent potentially deleterious mutations. The Silencer™ Human DNA Damage Response siRNA Library con

Transporter proteins play a key role in pharmacology, affecting how molecules are moved across cellular membranes. The Silencer™ Human Drug Transporter siRNA Library includes genes important to the absorption, distribution, metabolism and excretion of ma

Epigenetic regulation of gene expression is proving to be a key regulator in the development and progression of a host of human diseases. The Silencer™ Human Epigenetics siRNA Library contains 1,560 Ambion™ Silencer siRNAs targeting 520 epigenetic enzyme

Ion channels are key components in a multitude of biological processes, including rapid changes in muscle cell contractions, epithelial transport of nutrients and ions, T cell activation and pancreatic beta-cell insulin release. They are therefore a freq

Given their importance in cell signaling and many other biological pathways, kinases have become key drug targets. The Silencer™ Human Kinase siRNA Library contains 2127 Ambion™ Silencer siRNAs targeting 709 human kinase genes for performing RNAi screens

The Silencer™ Human Membrane Trafficking siRNA Library is designed for researchers targeting proteins known or predicted to participate in membrane trafficking or remodeling. This library is designed with an aim to understand gene expression in critical

The nuclear hormone receptor gene family includes receptors for thyroid and steroid hormones, retinoids and vitamin D, as well as receptors of unknown ligands. The Silencer™ Human Nuclear siRNA Library contains 141 Ambion™ Silencer siRNAs targeting 47 ge

Phosphatases are important regulators of biological pathways and cell signaling cascades. The Silencer™ Human Phosphatase siRNA Library contains 894 Ambion™ Silencer siRNAs targeting 298 human phosphatase genes . This library is designed using the most u

Proteases are molecules that play an important role in many normal biological processes and have been implicated in different human diseases. The Silencer™ Human Protease siRNA Library contains a panel of 1482 Ambion™ Silencer siRNAs targeting 494 human

Transcription factors are fast becoming promising drug targets, as they bind to and regulate the transcription of genes. The Silencer Human Transcription Factor siRNA Library targets genes expressing proteins that bind DNA in a sequence-specific manner t