Immunogen sequence: NKTVRKELLG MCFGDRYYRE PFVQRQRTSR LFSISNRITD LGLSPHLTAL MAGGQPLGHS SSTGDTGFSC SQDSGTDM. Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to