MIA-2 is a secreted cytokine, and a member of the MIA/OTOR family. Members of this family, which also includes MIA, OTOR, and TANGO, share a Src homology-3 (SH3)-like domain. MIA-2 is predominantly expressed in hepatocytes. Elevated levels of MIA-2 may represent a clinically useful marker for diagnosis of hepatic disease activity and severity. Recombinant Human MIA-2 is a 101 amino acid, 11.5 kDa protein comprising the MIA homologous N-terminal region of the full length MIA-2 protein.