Nesfatin-1 is a metabolic polypeptide encoded in the N-terminal region of the precursor protein, Nucleobindin2 (NUCB2). Originally identified as a hypothalamic neuropeptide, nesfatin-1 is also expressed in other areas of the brain, in pancreatic islets beta-cells, gastric endocrine cells, and adipocytes. Nesfatin-1 suppresses food intake and can regulate energy metabolism in a Leptin independent manner. Recombinant Human Nesfatin-1 is a 9.7 kDa protein containing 82 amino acid residues.