Tetra-n-butylammonium fluoride trihydrate is used as a phase transfer catalyst, as a mild base and as a source of fluoride ion in organic solvents. It is also used as a deprotecting agent to remove silyl ether protecting groups. It acts as a reactant for the preparation of deprotecting agents, in preparation of cellulose derivatives, lipophilic peptides for DNA transfections and Dehydrobromination reactions. It plays an important role in the convertion of O-silylated enolates in to carbonyls in the presence of dimethyl sulfoxide.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsTetra-n-butylammonium fluoride trihydrate is used as a phase transfer catalyst, as a mild base and as a source of fluoride ion in organic solvents. It is also used as a deprotecting agent to remove silyl ether protecting groups. It acts as a reactant for the preparation of deprotecting agents, in preparation of cellulose derivatives, lipophilic peptides for DNA transfections and Dehydrobromination reactions. It plays an important role in the convertion of O-silylated enolates in to carbonyls in the presence of dimethyl sulfoxide.
SolubilitySoluble in water, terahydrofuran, dimethyl sulfoxide and acetonitrile.
NotesHygroscopic. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.