Thiophene-3-carboxaldehyde has been used in the synthesis of series of 4-substituted 2-thiophenesulfonamides, acetal and ketal derivatives of 4?-demethylepipodophyllotoxin-β-D-glucoside and epipodophyllotoxin-β-D-glucoside. Also has been used to produce 1,2-di-3-thienyl-2-hydroxyethanone (3,3?-thenoin), 3-thienyl symmetric analog of benzoin.
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ApplicationsThiophene-3-carboxaldehyde has been used in the synthesis of series of 4-substituted 2-thiophenesulfonamides, acetal and ketal derivatives of 4′-demethylepipodophyllotoxin-β-D-glucoside and epipodophyllotoxin-β-D-glucoside. Also has been used to produce 1,2-di-3-thienyl-2-hydroxyethanone (3,3′-thenoin), 3-thienyl symmetric analog of benzoin.
SolubilityNot miscible in water.
NotesIt is sensitive to air. Incompatible with oxidizing agents and heat.