Immunogen sequence: LHCTEDPVPEA VGGDMQQLNQ LGAQQFSALT EVLFHFLTEP KEVERFLAQL SEFATTNQIS LGSLRSIVKS Highest antigen sequence identity to the following orthologs - mouse 90%, rat 93%. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes