Description: Deoxynivalenol (DON , Vomitoxin) is a type B trichothecene. It occurs in grains such as wheat, barley, oats, rye, and maize, rice, sorghum. Deoxynivalenol (DON) is produced by numerous strains of Fusarium and some other fungi. Deoxynivalenol (DON) poisonings occur both in humans and farm animals. Deoxynivalenol (DON) is highly toxic, producing a wide range of immunological disturbances and is particularly noted for inducing feed refusal and emesis in pigs, hence the alternative name vomitoxin Deoxynivalenol (DON) usually co-occurs with other Fusarium toxins, such as Zearalenone, Nivalenol and its derivates, as well as the group of fumonisins.
Solubility ( literature ): Deoxynivalenol (DON ) is soluble in common polar organic solvents as acetonitrile, methanol and ethyl acetate, slightly soluble in water.
Applications: The main toxic effect of Deoxynivalenol (DON) is inhibition of protein synthesis via binding to the ribosome.In agricultural R&D, DON is widely used to select crops strains with increased resistance against Fusarium.
Composition: Ingredient type Fermentek product
Disclaimer: For Research use only, Not for Human or Drug use, Not extracted from humans or animals, Refer to MSDS for further safety and handling instructions, Semi-Synthetic
Names and identifiers: Rd toxin Vomitoxin Deoxynivalenol 4-Deoxynivalenol Dehydronivalenol 4-Desoxynivalenol RTECS YD0167000
Pub 1: The Mycotoxin Deoxynivalenol Predisposes for the Development of Clostridium perfringens-Induced Necrotic Enteritis in Broiler Chickens Gunther Antonissen , Filip Van Immerseel , Frank Pasmans , Richard Ducatelle, Freddy Haesebrouck, Leen Timbermont, Marc Verlinden, Geert Paul Jules Janssens, Venessa Eeckhaut, Mia Eeckhout, Sarah De Saeger, Sabine Hessenberger, An Martel , Siska Croubels Published: September 30, 2014 http://dx.doi.org/10.1371/journal.pone.0108775
Source: Semisynthetic
Chemical name:
InChl Key: LINOMUASTDIRTM-QGRHZQQGSA-N