RELMalpha belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The four known members of this family, resistin, RELMalpha, RELMbeta, and RELMgamma, are 85-94 amino acid, secreted proteins sharing a conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELMalpha and resistin are secreted exclusively by adipocytes, while RELMbeta is expressed in the epithelium of the colon and small bowel. The physiological role and molecular targets of RELMalpha are still unknown. Recombinant Murine RELMalpha is a 10.0 kDa monomeric protein containing 89 amino acid residues.