Description: Chromomycin A3 is an antibiotic of the Anthraquinone group. It inhibits RNA synthesis by interfering with the binding of the transcription factors Sp1 and Sp3 to the DNA. Chromomycin A3 exhibits anti-bacterial, anti-fungal and antitumor activitie. Chromomycin A3 gains interest as a candidate anticancer drug. is also used as a fluorescent dye to determine DNA concentrations.
Solubility ( literature ): DMSO, Ethyl Acetate, Methanol, Ethanol
Applications: Membrane-impermeant, G/C-specific fluorescent DNA-binding dye. Antibacterial antibiotic. Antitumor antibiotic that inhibits RNA synthesis, especially in solid tumors.
Composition: Ingredient type Fermentek product
Disclaimer: For Research use only, Not for Human or Drug use, Not extracted from humans or animals, Refer to MSDS for further safety and handling instructions
Names and identifiers: Synonyms: Olivomycin D Toyomycin IUPAC name: (1S)-1-C-((2S,3S)-7-{[4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-D-lyxo-hexopyranosyl)-β-D-lyxo-hexopyranosyl]oxy}-3-{[4-O-acetyl-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy}-5,10-dihydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)-5-deoxy-1-O-methyl-D-xylulose RTECS GB7875000
Pub 1:
Source: Streptomyces griseus
Chemical name: Chromomycin A3
InChl Key: ZYVSOIYQKUDENJ-WKSBCEQHSA-N