Description: Geldanamycin is a benzoquinone ansamycin antibiotic, which binds to Hsp90 (Heat Shock Protein 90) and alters its function. Geldanamycin is a natural product from which several valuable derivates were synthesized. All derivates share its HSP90 inhibition, and vary in overall toxicity and water solubility.
Solubility ( literature ): Geldanamycin is soluble in DMSO, Dichloromethane. Geldanamycin is insoluble in water.
Applications: Exhibits potent antitumor activity. It also inhibits nuclear hormone receptors.
Composition: Ingredient type Fermentek product
Disclaimer: For Research use only, Not for Human or Drug use, Not extracted from humans or animals, Refer to MSDS for further safety and handling instructions
Names and identifiers: RTECS LX8920000 IUPAC Name : [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate I
Pub 1:
Source: Streptomyces Hygroscopicus var Geldanus
Chemical name:
InChl Key: QTQAWLPCGQOSGP-KSRBKZBZSA-N