Description: Unsaturated Fatty Acid polyketide with cytotoxic activity. Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins.
Solubility ( literature ):
Applications:
Composition: Ingredient type Fermentek product
Disclaimer: For Research use only, Not for Human or Drug use, Not extracted from humans or animals, Refer to MSDS for further safety and handling instructions
Names and identifiers: Synonyms: Antibiotic ATS 1287A Antibiotic PD 118607 Jildamycin Chemical names: Jildamycin Leptomycin A IUPAC: (2E,10E,12E,16Z,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid RTECS#: RA5391000
Pub 1:
Source: Streptomyces sp
Chemical name:
InChl Key: QECBVZBMGUAZDL-SJMSETAHSA-N