Description: Hexaoxygenated tetra-acylated sesquiterpene lactone tetraester isolated from roots of Thapsia garganica; it induces mast cell degranulation and histamine release; it is an analog of thapsigargin.
Solubility ( literature ):
Applications:
Composition: Ingredient type Fermentek product
Disclaimer: For Research use only, Not for Human or Drug use, Not extracted from humans or animals, Refer to MSDS for further safety and handling instructions
Names and identifiers: Synonyms: Hexanoic acid, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl ester Chemical names: IUPAC: (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-Acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methyl-2-butenoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl hexanoate RTECS# Not available
Pub 1: The ability of thapsigargin and thapsigargicin to activate cells involved in the inflammatory response. Ali H, Christensen SB, Foreman JC, Pearce FL, Piotrowski W, Thastrup O. Br J Pharmacol. 1985 Jul;85(3):705-12. doi: 10.1111/j.1476-5381.1985.tb10567.x. PMID: 2411328 Free PMC article. Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanoylphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis. Hakii H, Fujiki H, Suganuma M, Nakayasu M, Tahira T, Sugimura T, Scheuer PJ, Christensen SB. J Cancer Res Clin Oncol. 1986;111(3):177-81. doi: 10.1007/BF00389230. PMID: 2426275 Effects of Thapsigargicin on Ca2+ movements in L1210 cells permeabilized with Digitonin E. Oztetik Biomed Khim Sep-Oct 2009;55(5):651-62 PMID: 20017396 Effects of the sesquiterpene lactone tetraesters thapsigargicin and thapsigargin, from roots of Thapsia garganica L., on isolated spinach chloroplasts. Santarius KA, Falsone G, Haddad H. Toxicon. 1987;25(4):389-99. PMID: 3617076
Source: Thapsia garganica
Chemical name:
InChl Key: LXWLOFYIORKNSA-FFOGNQQCSA-N