Description: Wortmannin is a steroid metabolite of the fungus Talaromyces wortmannii. It is a specific covalent inhibitor of phosphoinositide 3-kinases. Wortmannin has been used as precursor of an experimental anti-cancer drug PX-866
Solubility ( literature ): DMSO, Methanol. Wortmannin is unstable in aqueous and ethanolic solutions.
Applications: Wortmannin is an inhibitor of phosphatidyl-inositol 3-kinase Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase. Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells. Wortmannin was shown to have enhancing influence on memory and impair learning abilities. .
Composition: Ingredient type Fermentek product
Disclaimer: For Research use only, Not for Human or Drug use, Not extracted from humans or animals, Refer to MSDS for further safety and handling instructions
Names and identifiers: Synonyms: Wartmannin Antibiotic SL-2052 Systematic Name: (1alpha,11alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan-3,7,17-trione RTECS: CB641000
Pub 1: United States Patent Application 20120114637 Wortmannin (lalpha,l lalpha)-l l-(acetyloxy)-l-(methoxymethyl)-2-oxaandrosta-5,8- dieno(6,5,4-bc)furan-3,7,17-trione) available from Fermentek Biotechnology is an antifungal antibiotic, that inhibits mTOR (Brunn et al., EMBO J, 15:5256-5267, 1996).
Source: Talaromyces (Penicillium) wortmannii
Chemical name: Wortmannin
InChl Key: QDLHCMPXEPAAMD-QAIWCSMKSA-N