Description: 17AAG, also known as "Tanespimycin", is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. 17AAG is less hepatotoxic than Geldanamycin.
Solubility ( literature ): DMSO, Methanol. The solubility of 17-AAG in DMSO is >10 mM. General tips for obtaining a higher concentration: Heating to 37°C and using ultrasonic bath is advisable.
Applications: This compound was mentioned as an anticancer medicine. Geldanamycin derivates all interfere with heat-shock proteins, especially HSP90. 17-AAG belongs to a class of drugs called heat shock protein 90 (Hsp90) inhibitors.
Composition: Ingredient type Fermentek product
Disclaimer: For Research use only, Not for Human or Drug use, Not extracted from humans or animals, Refer to MSDS for further safety and handling instructions, Semi-Synthetic
Names and identifiers: Synonyms Tanespimycin 17-(Allylamino)-17-demethoxy- geldanamycin 17AAG IUPAC name [(3S,5S,6R,7S,8E,10R,11S,12E,14E)-21-(allylamino)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-8,12,14,18,21-pentaen-10-yl] carbamate RTECS # LX8932000
Pub 1:
Source: Semisynthetic derivate of Geldanamycin
Chemical name: 17-Demethoxy-17-allylaminogeldanamycin;
InChl Key: AYUNIORJHRXIBJ-TXHRRWQRSA-N