Description: Antimycin A is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogues in the antimycin A class, mostly involving variation of the fatty acid ester chain length or adjacent alkyl starting unit. Antimycin A binds to cytochrome C reductase at the Qi site, inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A is widely used as a bioprobe of respiration and other applications with over 5,000 literature citations. Some of data brought in this page, such as Molecular Weight, relates to Antimycin A1
Solubility ( literature ): (lit) Antimycin A is soluble in DMSO at 2 mg/mL and in 95% ethanol at 50 mg/mL. It is also freely soluble in ether, acetone, and chloroform. It is insoluble in water.
Applications:
Composition: Ingredient type Fermentek product
Disclaimer: For Research use only, Not for Human or Drug use, Not extracted from humans or animals, Refer to MSDS for further safety and handling instructions
Names and identifiers: Synonyms: Antimycin A Antimycins A Antipiricullin Fintrol Virosin Chemical names: IUPAC: 3-[(3-Formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate RTECS# CD0350000
Pub 1: Oncol Rep. 2008 Sep;20(3):689-93. Antimycin A, as a mitochondrial electron transport inhibitor prevents the growth of human lung cancer A549 cells. Han YH(1), Kim SH, Kim SZ, Park WH.
Source: Streptomyces sp.
Chemical name:
InChl Key: UIFFUZWRFRDZJC-RBVQMQRASA-N