Description: Nigericin is a polyether antibiotic which affects ion transport and ATPase activity in mitochondria. Nigericin is produced by Streptomyces hygroscopicus. Nigericin, an ionophore and antibiotic, is supplied as a sodium salt. Nigericin is one of the compounds successfully tested as a feed additive, displaying a significant effect on milk production in cattle. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumor cell lines and some viruses, including HIV.
Solubility ( literature ): DMSO, Ethanol, petrol ether. Not soluble in water
Applications: Disrupts the membrane potential and stimulates ATPase activity in mitochondria.
Composition: Ingredient type Fermentek product
Disclaimer: For Research use only, Not for Human or Drug use, Not extracted from humans or animals, Refer to MSDS for further safety and handling instructions
Names and identifiers: Polyetherin A; Azalomycin M; Helixin C ; RTECS QT6825000
Pub 1: Nigericin, a new crystalline antibiotic from an unidentified streptomyces. Harned r.l. et al., Antibiot. Chemother. 1951, 1, 594. The structure of nigericin. Steinrauf l.k. et al., biochem. Biophys. Res. Commun. 1968, 33, 29. Nigericin-induced na+/h+ and k+/h+ exchange in synaptosomes: effect on [3h]gaba release. Rodriguez r. & sitges m., Neurochem. Res. 1996, 21, 889. Nigericin inhibits accumulation of the steroidogenic acute regulatory protein but not steroidogenesis. King s.r. et al., Mol. Cell. Endocrinol. 2000, 166, 147. Nigericin inhibits insulin-stimulated glucose transport in 3t3-l1 adipocytes. Chu c.y. et al., j. Cell. Biochem. 2002, 85, 83. Inhibitory effects of polyethers on human immunodeficiency virus replication. Nakamura m., Antimicrob. Ag. Chemother. 1992, 36, 492. Teratogenic effects of nigericin, a carboxylic ionophore ; vedel-macrander gc; hood rd ; teratology 33:47-51,1986 Altered membrane permeability to monovalent cations as a teratogenic mechanism: Teratogenic effects of nigericin, a carboxylic ionophore vedel gc; hood rd teratology 27(2):81a,1983 Export of a single drug molecule in two transport cycles by a multidrug efflux pump; Eitan Bibi at al., ; Nature communications; DOI: 10.1038/ncomms5615
Source: Streptomyces hygroscopicus
Chemical name:
InChl Key: MOYOTUKECQMGHE-NTQCAYBPSA-M