Description: Rapamycin (Sirolimus) is a macrolide compound that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus (Rapamycin) is a potent immunosuppressant. Sirolimus (Rapamycin) possesses both antifungal and antineoplastic properties.
Solubility ( literature ): Methanol, DMSO
Applications: Research applications: Rapamycin Sirolimus inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Rapamycin Sirolimus inhibits T-lymphocyte activation / proliferation occuring in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mechanism that is distinct from that of other immunosuppressing agents. Sirolimus also inhibits antibody production.
Composition: Ingredient type Fermentek product
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Names and identifiers: Synonyms: RAPA, Rapamune, Sirolimus, RPM, Antibiotic AY 22989 RTECS: VE6250000
Pub 1:
Source: Streptomyces hygroscopicus
Chemical name:
InChl Key: QFJCIRLUMZQUOT-HPLJOQBZSA-N