Description: Thapsigargin is a cell-permeable, tumor promoting sesquiterpene lactone. A tight-binding inhibitor of intracellular calcium (SERCA) pumps (sarco/endoplasmic reticulum Ca2+ ATPase). Chemically it is classified as a sesquiterpene lactone antibiotic. A study from the University of Nottingham showed promising results for its use against Covid-19 and other coronavirus.
Solubility ( literature ): DMSO, Acetonitril, Ethanol, Methanol, Dichloromethane
Applications:
Composition: Ingredient type Fermentek product
Disclaimer: For Research use only, Not for Human or Drug use, Not extracted from humans or animals, Refer to MSDS for further safety and handling instructions
Names and identifiers: Synonyms: octanoic acid {3S-[3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha]}-6-(acetoxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)-azuleno[4,5-b]furan-7-yl ester RTECS RH0352700
Pub 1: Viruses 2021, 13(2), 234; https://doi.org/10.3390/v13020234 Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus Kin-Chow Chang et al Viruses . 2020 Sep 27;12(10):1093 Thapsigargin at Non-Cytotoxic Levels Induces a Potent Host Antiviral Response that Blocks Influenza A Virus Replication Leah V Goulding, Kin-Chow Chang et al MOLECULAR AND CELLULAR BIOLOGY, Nov. 1995, p. 6262–6272 Vol. 15, No. 11 Role of EGR-1 in Thapsigargin-Inducible Apoptosis in the Melanoma Cell Line A375-C6 VIVEK M. RANGNEKAR et al. Biochemical journal January 1993 Volume 289, Issue 1 Inhibition of protein synthesis and early protein processing by thapsigargin in cultured cells W L Wong; M A Brostrom; G Kuznetsov; D Gmitter-Yellen; C O Brostrom Int J Mol Sci. 2020 Dec 22;22(1):4. Thapsigargin-From Traditional Medicine to Anticancer Drug. Jaskulska A, Janecka AE, Gach-Janczak K.
Source: Thapsia garganica
Chemical name:
InChl Key: IXFPJGBNCFXKPI-FSIHEZPISA-N